[HTML][HTML] A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
Dietary polyunsaturated fatty acids (PUFA) are negative regulators of hepatic lipogenesis
that exert their effects primarily at the level of transcription. Sterol regulatory element-binding
proteins (SREBPs) are transcription factors responsible for the regulation of cholesterol, fatty
acid, and triglyceride synthesis. In particular, SREBP-1 is known to play a crucial role in the
regulation of lipogenic gene expression in the liver. To explore the possible involvement of
SREBP-1 in the suppression of hepatic lipogenesis by PUFA, we challenged wild-type mice …
that exert their effects primarily at the level of transcription. Sterol regulatory element-binding
proteins (SREBPs) are transcription factors responsible for the regulation of cholesterol, fatty
acid, and triglyceride synthesis. In particular, SREBP-1 is known to play a crucial role in the
regulation of lipogenic gene expression in the liver. To explore the possible involvement of
SREBP-1 in the suppression of hepatic lipogenesis by PUFA, we challenged wild-type mice …