[HTML][HTML] Sterol response element-binding protein 1c (SREBP1c) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription
MK Mater, AP Thelen, DA Pan, DB Jump - Journal of Biological Chemistry, 1999 - ASBMB
Polyunsaturated fatty acids (PUFA) suppress hepatic lipogenic gene transcription through a
peroxisome proliferator activated receptor α (PPARα)-and cyclooxygenase-independent
mechanism. Recently, the sterol response element-binding protein 1 (SREBP1) was
implicated in the nutrient control of lipogenic gene expression. In this report, we have
assessed the role SREBP1 plays in the PUFA control of three hepatic genes, fatty acid
synthase, L-pyruvate kinase (LPK), and the S14 protein (S14). PUFA suppressed both the …
peroxisome proliferator activated receptor α (PPARα)-and cyclooxygenase-independent
mechanism. Recently, the sterol response element-binding protein 1 (SREBP1) was
implicated in the nutrient control of lipogenic gene expression. In this report, we have
assessed the role SREBP1 plays in the PUFA control of three hepatic genes, fatty acid
synthase, L-pyruvate kinase (LPK), and the S14 protein (S14). PUFA suppressed both the …