Quality control in the secretory pathway

C Hammond, A Helenius - Current opinion in cell biology, 1995 - Elsevier
C Hammond, A Helenius
Current opinion in cell biology, 1995Elsevier
Whereas newly synthesized proteins that have aquired a properly folded and assembled
structure are transported from the endoplasmic reticulum to their final destinations,
incompletely folded and assembled proteins are, as a rule, retained and eventually
degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called
'quality control', have been illuminated by recent studies.
Whereas newly synthesized proteins that have aquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called ‘quality control’, have been illuminated by recent studies.
Elsevier