Quality control in the secretory pathway
C Hammond, A Helenius - Current opinion in cell biology, 1995 - Elsevier
C Hammond, A Helenius
Current opinion in cell biology, 1995•ElsevierWhereas newly synthesized proteins that have aquired a properly folded and assembled
structure are transported from the endoplasmic reticulum to their final destinations,
incompletely folded and assembled proteins are, as a rule, retained and eventually
degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called
'quality control', have been illuminated by recent studies.
structure are transported from the endoplasmic reticulum to their final destinations,
incompletely folded and assembled proteins are, as a rule, retained and eventually
degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called
'quality control', have been illuminated by recent studies.
Whereas newly synthesized proteins that have aquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called ‘quality control’, have been illuminated by recent studies.
Elsevier