[CITATION][C] The mitogen-activated protein kinase signal transduction pathway

RJ Davis - Journal of Biological Chemistry, 1993 - Elsevier
Journal of Biological Chemistry, 1993Elsevier
Mitogen-activated protein (MAP)'kinases are important intermediates in signal transduction
pathways that are initiated by many types of cell surface receptors. The final common
pathway that is activated by these diverse agents is a protein kinase cascade involving MAP
kinase kinase kinase (c-Raf-1 (1-3), Mos (4), and Stell (5)), MAPkinase kinase(6), and MAP
kinase (Fig. 1). A significant property of MAP kinase activation is the requirement for both Thr
and Tyr phosphorylation within the protein kinase subdomain VI11 (7, 8). The purpose of this …
Mitogen-activated protein (MAP)'kinases are important intermediates in signal transduction pathways that are initiated by many types of cell surface receptors. The final common pathway that is activated by these diverse agents is a protein kinase cascade involving MAP kinase kinase kinase (c-Raf-1 (1-3), Mos (4), and Stell (5)), MAPkinase kinase(6), and MAP kinase (Fig. 1). A significant property of MAP kinase activation is the requirement for both Thr and Tyr phosphorylation within the protein kinase subdomain VI11 (7, 8). The purpose of this review is to summarize the results obtained in recent studies that have been designed to establish the significance of the activation of the MAP kinase isoforms ERKl and ERK2.
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