Role of Akt signaling in vascular homeostasis and angiogenesis

I Shiojima, K Walsh - Circulation research, 2002 - Am Heart Assoc
I Shiojima, K Walsh
Circulation research, 2002Am Heart Assoc
Akt is a serine/threonine protein kinase that is activated by a number of growth factors and
cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic
activity of Akt is well known, it also regulates other aspects of cellular functions, including
migration, glucose metabolism, and protein synthesis. In this review, Akt signaling in
endothelial cells and its critical roles in the regulation of vascular homeostasis and
angiogenesis will be discussed.
Akt is a serine/threonine protein kinase that is activated by a number of growth factors and cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic activity of Akt is well known, it also regulates other aspects of cellular functions, including migration, glucose metabolism, and protein synthesis. In this review, Akt signaling in endothelial cells and its critical roles in the regulation of vascular homeostasis and angiogenesis will be discussed.
Am Heart Assoc