[HTML][HTML] Oxidative Stress Increases Production of β-Amyloid Precursor Protein and β-Amyloid (Aβ) in Mammalian Lenses, and Aβ Has Toxic Effects on Lens Epithelial …
PH Frederikse, D Garland, JS Zigler… - Journal of Biological …, 1996 - ASBMB
Many amyloid diseases are characterized by protein aggregations linked to oxidative stress.
Such diseases including those of the brain, muscle, and blood vessels exhibit plaques
containing β-amyloid (Aβ). Here we demonstrate that Alzheimer's precursor protein (βAPP)
and Aβ are present at low levels in normal lenses and increase in intact cultured monkey
lenses treated with H 2 O 2 or UV radiation (known cataractogenic agents), and with phorbol
12-myristate 13-acetate. AP-1 factor binding, shown by others to up-regulate βAPP …
Such diseases including those of the brain, muscle, and blood vessels exhibit plaques
containing β-amyloid (Aβ). Here we demonstrate that Alzheimer's precursor protein (βAPP)
and Aβ are present at low levels in normal lenses and increase in intact cultured monkey
lenses treated with H 2 O 2 or UV radiation (known cataractogenic agents), and with phorbol
12-myristate 13-acetate. AP-1 factor binding, shown by others to up-regulate βAPP …