Biogenesis of respiratory complex I

U Schulte - Journal of bioenergetics and biomembranes, 2001 - Springer
U Schulte
Journal of bioenergetics and biomembranes, 2001Springer
Proteins specifically involved in the biogenesis of respiratory complex I in eukaryotes have
been characterized. The complex I intermediate associated proteins CIA30 and CIA84 are
tightly bound to an assembly intermediate of the membrane arm. Like chaperones, they are
involved in multiple rounds of membrane arm assembly without being part of the mature
structure. Two biosynthetic subunits of eukaryotic complex I have been characterized. The
acyl carrier subunit is needed for proper assembly of the peripheral arm as well as the …
Abstract
Proteins specifically involved in the biogenesis of respiratory complex I in eukaryotes have been characterized. The complex I intermediate associated proteins CIA30 and CIA84 are tightly bound to an assembly intermediate of the membrane arm. Like chaperones, they are involved in multiple rounds of membrane arm assembly without being part of the mature structure. Two biosynthetic subunits of eukaryotic complex I have been characterized. The acyl carrier subunit is needed for proper assembly of the peripheral arm as well as the membrane arm of complex I. It may interact with enzymes of a mitochondrial fatty acid synthetase. The 39/40-kDa subunit appears to be an isomerase with a tightly bound NADPH. It is related to a protein family of reductases/isomerases. Both subunits have been discussed to be involved in the synthesis of a postulated, novel, high-potential redox group.
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