[HTML][HTML] Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60Src
KG Birukov, C Csortos, L Marzilli, S Dudek… - Journal of Biological …, 2001 - ASBMB
The Ca 2+/calmodulin-dependent endothelial cell myosin light chain kinase (MLCK) triggers
actomyosin contraction essential for vascular barrier regulation and leukocyte diapedesis.
Two high molecular weight MLCK splice variants, EC MLCK-1 and EC MLCK-2 (210–214
kDa), in human endothelium are identical except for a deleted single exon in MLCK-2
encoding a 69-amino acid stretch (amino acids 436–505) that contains potentially important
consensus sites for phosphorylation by p60 Src kinase (Lazar, V., and Garcia, JG (1999) …
actomyosin contraction essential for vascular barrier regulation and leukocyte diapedesis.
Two high molecular weight MLCK splice variants, EC MLCK-1 and EC MLCK-2 (210–214
kDa), in human endothelium are identical except for a deleted single exon in MLCK-2
encoding a 69-amino acid stretch (amino acids 436–505) that contains potentially important
consensus sites for phosphorylation by p60 Src kinase (Lazar, V., and Garcia, JG (1999) …