[HTML][HTML] Uth1p is involved in the autophagic degradation of mitochondria
I Kissová, M Deffieu, S Manon… - Journal of Biological …, 2004 - ASBMB
The absence of the outer mitochondrial membrane protein Uth1p was found to induce
resistance to rapamycin treatment and starvation, two conditions that induce the autophagic
process. Biochemical studies showed the onset of a fully active autophagic activity both in
wild-type and Δuth1 strains. On the other hand, the disorganization of the mitochondrial
network induced by rapamycin treatment or 15 h of nitrogen starvation was followed in cells
expressing mitochondria-targeted green fluorescent protein; a rapid colocalization of green …
resistance to rapamycin treatment and starvation, two conditions that induce the autophagic
process. Biochemical studies showed the onset of a fully active autophagic activity both in
wild-type and Δuth1 strains. On the other hand, the disorganization of the mitochondrial
network induced by rapamycin treatment or 15 h of nitrogen starvation was followed in cells
expressing mitochondria-targeted green fluorescent protein; a rapid colocalization of green …