[HTML][HTML] Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

A Petiot, E Ogier-Denis, EFC Blommaart… - Journal of Biological …, 2000 - ASBMB
3-Methyladenine which stops macroautophagy at the sequestration step in mammalian cells
also inhibits the phosphoinositide 3-kinase (PI3K) activity raising the possibility that PI3K
signaling controls the macroautophagic pathway (Blommaart, EFC, Krause, U., Schellens,
JPM, Vreeling-Sindelárová, H., and Meijer, AJ (1997) Eur. J. Biochem. 243, 240–246). The
aim of this study was to identify PI3Ks involved in the control of macroautophagic
sequestration in human colon cancer HT-29 cells. An increase of class I PI3K products …