Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides
We demonstrate that antimicrobial peptides induce an autophagic cell death in the
protozoan pathogen, Leishmania donovani. In our study, three antimicrobial peptides,
Indolicidin, and two peptides derived from Seminalplasmin exhibit antileishmanial activity
with a 50% lethal dose of 3.5× 10− 5, 3.8× 10− 4 and 1.7× 10− 8μM, respectively. The action
of these antimicrobial peptides on the Leishmania cell involves ionic interactions, which are
modulated by lipophosphoglycan on the parasite's surface. Peptide treatment caused …
protozoan pathogen, Leishmania donovani. In our study, three antimicrobial peptides,
Indolicidin, and two peptides derived from Seminalplasmin exhibit antileishmanial activity
with a 50% lethal dose of 3.5× 10− 5, 3.8× 10− 4 and 1.7× 10− 8μM, respectively. The action
of these antimicrobial peptides on the Leishmania cell involves ionic interactions, which are
modulated by lipophosphoglycan on the parasite's surface. Peptide treatment caused …