[HTML][HTML] Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ
CR Arnt, MV Chiorean, MP Heldebrant… - Journal of Biological …, 2002 - ASBMB
Inhibitor of apoptosis proteins (IAPs) interact with and inhibit caspases-3,-7, and-9. This
interaction can be inhibited by Smac/DIABLO, a polypeptide released from mitochondria
upon initiation of the apoptotic signaling process. Here we demonstrate that the first 4–8 N-
terminal amino acids of Smac/DIABLO fused to theDrosophila antennapaedia penetratin
sequence, a carrier peptide, enhance the induction of apoptosis and long term
antiproliferative effects of diverse antineoplastic agents including paclitaxel, etoposide, 7 …
interaction can be inhibited by Smac/DIABLO, a polypeptide released from mitochondria
upon initiation of the apoptotic signaling process. Here we demonstrate that the first 4–8 N-
terminal amino acids of Smac/DIABLO fused to theDrosophila antennapaedia penetratin
sequence, a carrier peptide, enhance the induction of apoptosis and long term
antiproliferative effects of diverse antineoplastic agents including paclitaxel, etoposide, 7 …