[HTML][HTML] The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
The inhibitor-of-apoptosis proteins (IAPs) play a critical role in the regulation of apoptosis by
binding and inhibiting caspases. Reaper family proteins and Smac/DIABLO use a conserved
amino-terminal sequence to bind to IAPs in flies and mammals, respectively, blocking their
ability to inhibit caspases and thus promoting apoptosis. Here we have identified the serine
protease Omi/HtrA2 as a second mammalian XIAP-binding protein with a Reaper-like motif.
This protease autoprocesses to form a protein with amino-terminal homology to …
binding and inhibiting caspases. Reaper family proteins and Smac/DIABLO use a conserved
amino-terminal sequence to bind to IAPs in flies and mammals, respectively, blocking their
ability to inhibit caspases and thus promoting apoptosis. Here we have identified the serine
protease Omi/HtrA2 as a second mammalian XIAP-binding protein with a Reaper-like motif.
This protease autoprocesses to form a protein with amino-terminal homology to …