[HTML][HTML] Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

FC Kischkel, DA Lawrence, A Tinel, H LeBlanc… - Journal of Biological …, 2001 - ASBMB
Caspase-8 is believed to play an obligatory role in apoptosis initiation by death receptors,
but the role of its structural relative, caspase-10, remains controversial. Although earlier
evidence implicated caspase-10 in apoptosis signaling by CD95L and Apo2L/TRAIL, recent
studies indicated that these death receptor ligands recruit caspase-8 but not caspase-10 to
their death-inducing signaling complex (DISC) even in presence of abundant caspase-10.
We characterized a series of caspase-10-specific antibodies and found that certain …