[HTML][HTML] Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHα1) death signal
DA Martin, RM Siegel, L Zheng, MJ Lenardo - Journal of Biological …, 1998 - ASBMB
Many forms of apoptosis, including that caused by the death receptor CD95/Fas/APO-1,
depend on the activation of caspases, which are proteases that cleave specific intracellular
proteins to cause orderly cellular disintegration. The requirements for activating these crucial
enzymatic mediators of death are not well understood. Using molecular chimeras with either
CD8 or Tac, we find that oligomerization at the cell membrane powerfully induces caspase-8
autoactivation and apoptosis. Death induction was abrogated by the z-VAD-fmk, z-IETD-fmk …
depend on the activation of caspases, which are proteases that cleave specific intracellular
proteins to cause orderly cellular disintegration. The requirements for activating these crucial
enzymatic mediators of death are not well understood. Using molecular chimeras with either
CD8 or Tac, we find that oligomerization at the cell membrane powerfully induces caspase-8
autoactivation and apoptosis. Death induction was abrogated by the z-VAD-fmk, z-IETD-fmk …