[HTML][HTML] FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b
C Scaffidi, JP Medema, PH Krammer… - Journal of Biological …, 1997 - ASBMB
Induction of apoptosis by the cell surface receptor CD95 (APO-1/Fas) has been shown to
involve activation of a family of cysteine proteases (caspases). Recently, a new member of
this family has been identified, designated FLICE (caspase-8/MACH/Mch5). FLICE is part of
the CD95 death-inducing signaling complex and is therefore the most upstream caspase in
the CD95 apoptotic pathway. A total of eight different isoforms of FLICE (caspase-8/a–h)
have been described. To determine which isoforms are expressed in different cells we have …
involve activation of a family of cysteine proteases (caspases). Recently, a new member of
this family has been identified, designated FLICE (caspase-8/MACH/Mch5). FLICE is part of
the CD95 death-inducing signaling complex and is therefore the most upstream caspase in
the CD95 apoptotic pathway. A total of eight different isoforms of FLICE (caspase-8/a–h)
have been described. To determine which isoforms are expressed in different cells we have …