[PDF][PDF] Mechanisms of caspase activation and inhibition during apoptosis
Y Shi - Molecular cell, 2002 - cell.com
Molecular cell, 2002•cell.com
Caspases are central components of the machinery responsible for apoptosis. Recent
structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome
have revealed a conserved mechanism of caspase activation and inhibition. This article
reviews these latest advances and presents our current understanding of caspase
regulation during apoptosis.
structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome
have revealed a conserved mechanism of caspase activation and inhibition. This article
reviews these latest advances and presents our current understanding of caspase
regulation during apoptosis.
Abstract
Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews these latest advances and presents our current understanding of caspase regulation during apoptosis.
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