Bcl-2 family proteins as ion-channels
SL Schendel, M Montal, JC Reed - Cell Death & Differentiation, 1998 - nature.com
SL Schendel, M Montal, JC Reed
Cell Death & Differentiation, 1998•nature.comThe Bcl-2 protein family function (s) as important regulators of cellular decisions to heed or
ignore death signals. The three-dimensional structure of the Bcl-2 homolog, Bcl-X L, bears a
strong resemblance to some pore-forming bacterial toxins. This similarity suggested that the
Bcl-2 family proteins may also possess channel-forming capability. This review summarizes
the recent initial studies on the in vitro channel activity of Bcl-2, Bcl-X L and Bax and offers
some speculation as to the physiological role that these channels may play in the cell death …
ignore death signals. The three-dimensional structure of the Bcl-2 homolog, Bcl-X L, bears a
strong resemblance to some pore-forming bacterial toxins. This similarity suggested that the
Bcl-2 family proteins may also possess channel-forming capability. This review summarizes
the recent initial studies on the in vitro channel activity of Bcl-2, Bcl-X L and Bax and offers
some speculation as to the physiological role that these channels may play in the cell death …
Abstract
The Bcl-2 protein family function (s) as important regulators of cellular decisions to heed or ignore death signals. The three-dimensional structure of the Bcl-2 homolog, Bcl-X L, bears a strong resemblance to some pore-forming bacterial toxins. This similarity suggested that the Bcl-2 family proteins may also possess channel-forming capability. This review summarizes the recent initial studies on the in vitro channel activity of Bcl-2, Bcl-X L and Bax and offers some speculation as to the physiological role that these channels may play in the cell death pathway.
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