Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction
W Paschen, C Gissel, T Linden, S Althausen… - Molecular brain …, 1998 - Elsevier
The expression of the gene encoding the C/EBP-homologous protein (CHOP), which is also
known as growth arrest and DNA-damage-inducible gene 153 (gadd153), has been shown
to be specifically activated under conditions that disturb the functioning of the endoplasmic
reticulum (ER). To investigate a possible role of ER dysfunction in the pathological process
of ischemic cell damage, we studied ischemia-induced changes in gadd153 expression
using quantitative PCR. Transient cerebral ischemia was produced in rats by four-vessel …
known as growth arrest and DNA-damage-inducible gene 153 (gadd153), has been shown
to be specifically activated under conditions that disturb the functioning of the endoplasmic
reticulum (ER). To investigate a possible role of ER dysfunction in the pathological process
of ischemic cell damage, we studied ischemia-induced changes in gadd153 expression
using quantitative PCR. Transient cerebral ischemia was produced in rats by four-vessel …