Manganese is known to cause central nervous system injury leading to parkinsonism and to
contribute to the pathogenesis of hepatic encephalopathy. Although mechanisms of
manganese neurotoxicity are not completely understood, chronic exposure of various cell
types to manganese has shown oxidative stress and mitochondrial energy failure, factors
that are often implicated in the induction of the mitochondrial permeability transition (MPT).
In this study, we examined whether exposure of cultured neurons and astrocytes to …