[HTML][HTML] Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase
K Noguchi, C Kitanaka, H Yamana, A Kokubu… - Journal of Biological …, 1999 - ASBMB
The expression of c-myc promotes cell proliferation and also sensitizes cells to various
extracellular apoptotic stimuli. However, signal pathways regulating the function of Myc
proteins during apoptosis are unknown. c-Jun N-terminal kinase (JNK) is activated by
various apoptotic stimuli, but neither the target molecule (s) or the action of JNK has been
identified in Myc-mediated apoptosis. Here, we found that JNK selectively interacted with,
and phosphorylated, c-Myc at Ser-62 and Ser-71 as confirmed with phospho-c-Myc-specific …
extracellular apoptotic stimuli. However, signal pathways regulating the function of Myc
proteins during apoptosis are unknown. c-Jun N-terminal kinase (JNK) is activated by
various apoptotic stimuli, but neither the target molecule (s) or the action of JNK has been
identified in Myc-mediated apoptosis. Here, we found that JNK selectively interacted with,
and phosphorylated, c-Myc at Ser-62 and Ser-71 as confirmed with phospho-c-Myc-specific …