[HTML][HTML] hsp72 inhibits focal adhesion kinase degradation in ATP-depleted renal epithelial cells
H Mao, F Li, K Ruchalski, DD Mosser… - Journal of Biological …, 2003 - ASBMB
Prior heat stress (HS) or the selective overexpression of hsp72 prevents apoptosis caused
by exposure to metabolic inhibitors by protecting the mitochondrial membrane and partially
reducing caspase-3 activation. Focal adhesion kinase (FAK), a tyrosine kinase, exhibits anti-
apoptotic properties and is a potential target for degradation by caspase-3. This study tested
the hypothesis that hsp72 interacts with FAK, preventing caspase-3-mediated degradation
during ATP depletion. ATP depletion (5 mmNaCN and 5 mm 2-deoxy-d-glucose in the …
by exposure to metabolic inhibitors by protecting the mitochondrial membrane and partially
reducing caspase-3 activation. Focal adhesion kinase (FAK), a tyrosine kinase, exhibits anti-
apoptotic properties and is a potential target for degradation by caspase-3. This study tested
the hypothesis that hsp72 interacts with FAK, preventing caspase-3-mediated degradation
during ATP depletion. ATP depletion (5 mmNaCN and 5 mm 2-deoxy-d-glucose in the …