[HTML][HTML] Small stress proteins as novel regulators of apoptosis: heat shock protein 27 blocks Fas/APO-1-and staurosporine-induced cell death
P Mehlen, K Schulze-Osthoff, AP Arrigo - Journal of Biological Chemistry, 1996 - ASBMB
Small stress protein expression enhances the survival of mammalian cells exposed to
numerous injuries that induce necrotic cell death. The cell surface receptor Fas/APO-1 and
its ligand have been recently identified as important mediators of apoptosis. Here, we show
that constitutive expression of human heat shock protein (hsp) 27 in murine L929 cells
blocks Fas/APO-1-mediated cell death. Expression of human hsp27 prevented anti-APO-1-
induced DNA fragmentation and morphological changes. These results strongly suggest that …
numerous injuries that induce necrotic cell death. The cell surface receptor Fas/APO-1 and
its ligand have been recently identified as important mediators of apoptosis. Here, we show
that constitutive expression of human heat shock protein (hsp) 27 in murine L929 cells
blocks Fas/APO-1-mediated cell death. Expression of human hsp27 prevented anti-APO-1-
induced DNA fragmentation and morphological changes. These results strongly suggest that …