[HTML][HTML] p53 induces NF-κB activation by an IκB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
J Bohuslav, L Chen, H Kwon, Y Mu… - Journal of Biological …, 2004 - ASBMB
Apoptosis induced by p53 has been proposed to involve activation of the transcription factor
NF-κB. Here we describe the novel molecular mechanism through which p53 and DNA-
damaging agents activate NF-κB. NF-κB induction by p53 does not occur through classical
activation of the IκB kinases and degradation of IκBα. Rather, p53 expression stimulates the
serine/threonine kinase ribosomal S6 kinase 1 (RSK1), which in turn phosphorylates the
p65 subunit of NF-κB. The lower affinity of RSK1-phosphorylated p65 for its negative …
NF-κB. Here we describe the novel molecular mechanism through which p53 and DNA-
damaging agents activate NF-κB. NF-κB induction by p53 does not occur through classical
activation of the IκB kinases and degradation of IκBα. Rather, p53 expression stimulates the
serine/threonine kinase ribosomal S6 kinase 1 (RSK1), which in turn phosphorylates the
p65 subunit of NF-κB. The lower affinity of RSK1-phosphorylated p65 for its negative …