[HTML][HTML] NF-κB activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells
X Bian, LM McAllister-Lucas, F Shao… - Journal of Biological …, 2001 - ASBMB
Neuroblastoma is the most common extracranial solid tumor of childhood. N-type
neuroblastoma cells (represented by SH-SY5Y and IMR32 cell lines) are characterized by a
neuronal phenotype. N-type cell lines are generally N-myc amplified, express the anti-
apoptotic protein Bcl-2, and do not express caspase-8. The present study was designed to
determine the mechanism by which N-type cells die in response to specific cytotoxic agents
(such as cisplatin and doxorubicin) commonly used to treat this disease. We found that N …
neuroblastoma cells (represented by SH-SY5Y and IMR32 cell lines) are characterized by a
neuronal phenotype. N-type cell lines are generally N-myc amplified, express the anti-
apoptotic protein Bcl-2, and do not express caspase-8. The present study was designed to
determine the mechanism by which N-type cells die in response to specific cytotoxic agents
(such as cisplatin and doxorubicin) commonly used to treat this disease. We found that N …