[HTML][HTML] Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002
MD Jacobs, J Black, O Futer, L Swenson, B Hare… - Journal of Biological …, 2005 - ASBMB
Pim-1 is an oncogene-encoded serine/threonine kinase primarily expressed in
hematopoietic and germ cell lines. Pim-1 kinase was originally identified in Maloney murine
leukemia virus-induced T-cell lymphomas and is associated with multiple cellular functions
such as proliferation, survival, differentiation, apoptosis, and tumorigenesis (Wang, Z.,
Bhattacharya, N., Weaver, M., Petersen, K., Meyer, M., Gapter, L., and Magnuson, NS (2001)
J. Vet. Sci. 2, 167–179). The crystal structures of Pim-1 complexed with staurosporine and …
hematopoietic and germ cell lines. Pim-1 kinase was originally identified in Maloney murine
leukemia virus-induced T-cell lymphomas and is associated with multiple cellular functions
such as proliferation, survival, differentiation, apoptosis, and tumorigenesis (Wang, Z.,
Bhattacharya, N., Weaver, M., Petersen, K., Meyer, M., Gapter, L., and Magnuson, NS (2001)
J. Vet. Sci. 2, 167–179). The crystal structures of Pim-1 complexed with staurosporine and …