Involvement of Akt kinase in the action of STI571 on chronic myelogenous leukemia cells
K Kawauchi, T Ogasawara, M Yasuyama… - Blood Cells, Molecules …, 2003 - Elsevier
To elucidate the role of mitogen-activated protein kinases (MAPKs) and Akt kinase in
leukemogenesis caused by the breakpoint cluster region (BCR)–Abelson (ABL) tyrosine
kinase oncoprotein, we examined the activities of MAPKs and Akt kinase and their roles in
the action of STI571, a specific inhibitor of BCR-ABL tyrosine kinase, in chronic
myelogenous leukemia (CML) cells. We found that extracellular signal-regulated kinase
(ERK) 1/2 and Akt kinase are constitutively active in the chronic phase of CML, blast crisis of …
leukemogenesis caused by the breakpoint cluster region (BCR)–Abelson (ABL) tyrosine
kinase oncoprotein, we examined the activities of MAPKs and Akt kinase and their roles in
the action of STI571, a specific inhibitor of BCR-ABL tyrosine kinase, in chronic
myelogenous leukemia (CML) cells. We found that extracellular signal-regulated kinase
(ERK) 1/2 and Akt kinase are constitutively active in the chronic phase of CML, blast crisis of …