Correction of hypocitraturia and prevention of stone formation by combined thiazide and potassium citrate therapy in thiazide-unresponsive hypercalciuric …
CYC Pak, R Peterson, K Sakhaee, C Fuller… - The American journal of …, 1985 - Elsevier
Thirteen patients with hypercalciuric calcium nephrolithiasis continued to form calcium
stones when treated with thiazide (4.69±6.62 [mean±SD] stones per patient-year to
5.12±10.87 stones per patient-year), despite adequate hypocalciuric response (a reduction
in urinary calcium levels from 303±119 mg per day to 193±88 mg per day, p< 0.01).
Because they had hypocitraturia (250±86 mg per day versus 643±236 mg per day in normal
subjects, p< 0.001), potassium citrate (10 to 20 meq three times per day) was added to the …
stones when treated with thiazide (4.69±6.62 [mean±SD] stones per patient-year to
5.12±10.87 stones per patient-year), despite adequate hypocalciuric response (a reduction
in urinary calcium levels from 303±119 mg per day to 193±88 mg per day, p< 0.01).
Because they had hypocitraturia (250±86 mg per day versus 643±236 mg per day in normal
subjects, p< 0.001), potassium citrate (10 to 20 meq three times per day) was added to the …