Hypercalciuria is an important, identifiable, and reversible risk factor in stone formation. The
foremost and most fundamental step in dissecting the genetics of hypercalciuria is
understanding its pathophysiology. Hypercalciuria is a complex trait. This article outlines the
various factors that compromise the attempt to dissect the genetics of hypercalciuria,
summarizes the clinical and experimental monogenic causes of hypercalciuria, and outlines
the initial results from attempts in studying polygenic hypercalciuria. Finally, the problem is …