Requirement for Vα14 NKT Cells in IL-12-Mediated Rejection of Tumors
J Cui, T Shin, T Kawano, H Sato, E Kondo, I Toura… - Science, 1997 - science.org
J Cui, T Shin, T Kawano, H Sato, E Kondo, I Toura, Y Kaneko, H Koseki, M Kanno…
Science, 1997•science.orgA lymphocyte subpopulation, the Vα14 natural killer T (NKT) cells, expresses both NK1. 1
and a single invariant T cell receptor encoded by the Vα14 and Jα281 gene segments. Mice
with a deletion of the Jα281 gene segment were found to exclusively lack this
subpopulation. The Vα14 NKT cell–deficient mice could no longer mediate the interleukin-
12 (IL-12)–induced rejection of tumors. Although the antitumor effect of IL-12 was thought to
be mediated through natural killer cells and T cells, Vα14 NKT cells were found to be an …
and a single invariant T cell receptor encoded by the Vα14 and Jα281 gene segments. Mice
with a deletion of the Jα281 gene segment were found to exclusively lack this
subpopulation. The Vα14 NKT cell–deficient mice could no longer mediate the interleukin-
12 (IL-12)–induced rejection of tumors. Although the antitumor effect of IL-12 was thought to
be mediated through natural killer cells and T cells, Vα14 NKT cells were found to be an …
A lymphocyte subpopulation, the Vα14 natural killer T (NKT) cells, expresses both NK1.1 and a single invariant T cell receptor encoded by the Vα14 and Jα281 gene segments. Mice with a deletion of the Jα281 gene segment were found to exclusively lack this subpopulation. The Vα14 NKT cell–deficient mice could no longer mediate the interleukin-12 (IL-12)–induced rejection of tumors. Although the antitumor effect of IL-12 was thought to be mediated through natural killer cells and T cells, Vα14 NKT cells were found to be an essential target of IL-12, and they mediated their cytotoxicity by an NK-like effector mechanism after activation with IL-12.
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