[HTML][HTML] Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
KJ Barnham, GD Ciccotosto, AK Tickler, FE Ali… - Journal of Biological …, 2003 - ASBMB
The amyloid β peptide is toxic to neurons, and it is believed that this toxicity plays a central
role in the progression of Alzheimer's disease. The mechanism of this toxicity is contentious.
Here we report that an Aβ peptide with the sulfur atom of Met-35 oxidized to a sulfoxide (Met
(O) Aβ) is toxic to neuronal cells, and this toxicity is attenuated by the metal chelator
clioquinol and completely rescued by catalase implicating the same toxicity mechanism as
reduced Aβ. However, unlike the unoxidized peptide, Met (O) Aβ is unable to penetrate lipid …
role in the progression of Alzheimer's disease. The mechanism of this toxicity is contentious.
Here we report that an Aβ peptide with the sulfur atom of Met-35 oxidized to a sulfoxide (Met
(O) Aβ) is toxic to neuronal cells, and this toxicity is attenuated by the metal chelator
clioquinol and completely rescued by catalase implicating the same toxicity mechanism as
reduced Aβ. However, unlike the unoxidized peptide, Met (O) Aβ is unable to penetrate lipid …