[HTML][HTML] Methylation of the imidazole side chains of the Alzheimer disease amyloid-β peptide results in abolition of superoxide dismutase-like structures and inhibition …
AK Tickler, DG Smith, GD Ciccotosto, DJ Tew… - Journal of Biological …, 2005 - ASBMB
The toxicity of the amyloid-β peptide (Aβ) is thought to be responsible for the
neurodegeneration associated with Alzheimer disease. Generation of hydrogen peroxide
has been implicated as a key step in the toxic pathway. Aβ coordinates the redox active
metal ion Cu 2+ to catalytically generate H 2 O 2. Structural studies on the interaction of Aβ
with Cu have suggested that the coordination sphere about the Cu 2+ resembles the active
site of superoxide dismutase 1. To investigate the potential role for such structures in the …
neurodegeneration associated with Alzheimer disease. Generation of hydrogen peroxide
has been implicated as a key step in the toxic pathway. Aβ coordinates the redox active
metal ion Cu 2+ to catalytically generate H 2 O 2. Structural studies on the interaction of Aβ
with Cu have suggested that the coordination sphere about the Cu 2+ resembles the active
site of superoxide dismutase 1. To investigate the potential role for such structures in the …