[HTML][HTML] Metalloenzyme-like activity of Alzheimer's disease β-amyloid: Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to …
C Opazo, X Huang, RA Cherny, RD Moir… - Journal of Biological …, 2002 - ASBMB
β-Amyloid (Aβ) 1–42, implicated in the pathogenesis of Alzheimer's disease, forms an
oligomeric complex that binds copper at a CuZn superoxide dismutase-like binding site. Aβ·
Cu complexes generate neurotoxic H 2 O 2 from O 2 through Cu 2+ reduction, but the
reaction mechanism has been unclear. We now report that Aβ1–42, when binding up to 2 eq
of Cu 2+, generates the H 2 O 2 catalytically by recruiting biological reducing agents as
substrates under conditions where the Cu 2+ or reducing agents will not form H 2 O 2 …
oligomeric complex that binds copper at a CuZn superoxide dismutase-like binding site. Aβ·
Cu complexes generate neurotoxic H 2 O 2 from O 2 through Cu 2+ reduction, but the
reaction mechanism has been unclear. We now report that Aβ1–42, when binding up to 2 eq
of Cu 2+, generates the H 2 O 2 catalytically by recruiting biological reducing agents as
substrates under conditions where the Cu 2+ or reducing agents will not form H 2 O 2 …