[HTML][HTML] Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-β peptide with membrane lipid
The interaction of Aβ peptides with the lipid matrix of neuronal cell membranes plays an
important role in the pathogenesis of Alzheimer's disease. By using EPR and CD
spectroscopy, we found that in the presence of Cu 2+ or Zn 2+, pH, cholesterol, and the
length of the peptide chain influenced the interaction of these peptides with lipid bilayers. In
the presence of Zn 2+, Aβ40 and Aβ42 both inserted into the bilayer over the pH range 5.5–
7.5, as did Aβ42 in the presence of Cu 2+. However, Aβ40 only penetrated the lipid bilayer …
important role in the pathogenesis of Alzheimer's disease. By using EPR and CD
spectroscopy, we found that in the presence of Cu 2+ or Zn 2+, pH, cholesterol, and the
length of the peptide chain influenced the interaction of these peptides with lipid bilayers. In
the presence of Zn 2+, Aβ40 and Aβ42 both inserted into the bilayer over the pH range 5.5–
7.5, as did Aβ42 in the presence of Cu 2+. However, Aβ40 only penetrated the lipid bilayer …