An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3).
SR Burrows, TB Sculley, IS Misko, C Schmidt… - The Journal of …, 1990 - rupress.org
SR Burrows, TB Sculley, IS Misko, C Schmidt, DJ Moss
The Journal of experimental medicine, 1990•rupress.orgEpstein-Barr virus (EBV)-specific CTL clones were isolated that recognized A-type EBV
transformants but not B-type transformants. These A-type-specific CTL clones (HLA B8
restricted) were used to screen peptides derived from the EBV nuclear antigens (EBNAs) 2,
3, 4, and 6 as potential CTL epitopes. Of the 76 peptides screened, one sequence from
EBNA 3 (residues 329-353) was recognized by A-type-specific CTL clones after absorption
onto target cells (either autologous B-type transformants or PHA blasts). This report is the …
transformants but not B-type transformants. These A-type-specific CTL clones (HLA B8
restricted) were used to screen peptides derived from the EBV nuclear antigens (EBNAs) 2,
3, 4, and 6 as potential CTL epitopes. Of the 76 peptides screened, one sequence from
EBNA 3 (residues 329-353) was recognized by A-type-specific CTL clones after absorption
onto target cells (either autologous B-type transformants or PHA blasts). This report is the …
Epstein-Barr virus (EBV)-specific CTL clones were isolated that recognized A-type EBV transformants but not B-type transformants. These A-type-specific CTL clones (HLA B8 restricted) were used to screen peptides derived from the EBV nuclear antigens (EBNAs) 2, 3, 4, and 6 as potential CTL epitopes. Of the 76 peptides screened, one sequence from EBNA 3 (residues 329-353) was recognized by A-type-specific CTL clones after absorption onto target cells (either autologous B-type transformants or PHA blasts). This report is the first description of an EBV target epitope recognized by specific CTL clones.
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