[HTML][HTML] Mechanisms that mediate negative regulation of the thyroid-stimulating hormone α gene by the thyroid hormone receptor
T Tagami, Y Park, JL Jameson - Journal of Biological Chemistry, 1999 - ASBMB
A group of transcriptional cofactors for nuclear hormone receptors, referred to as
corepressors (CoRs) and coactivators (CoAs), has been shown to induce transcriptional
silencing and hormone-induced activation, respectively, of genes that contain positive
hormone response elements. Transcriptional silencing by CoRs involves the recruitment of
histone deacetylases (HDACs), whereas ligand-dependent activation is associated with the
recruitment of CoAs, which possess or recruit histone acetyltransferases (HATs). In a …
corepressors (CoRs) and coactivators (CoAs), has been shown to induce transcriptional
silencing and hormone-induced activation, respectively, of genes that contain positive
hormone response elements. Transcriptional silencing by CoRs involves the recruitment of
histone deacetylases (HDACs), whereas ligand-dependent activation is associated with the
recruitment of CoAs, which possess or recruit histone acetyltransferases (HATs). In a …