IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men
E Jouanguy, R Döffinger, S Dupuis, A Pallier… - Current opinion in …, 1999 - Elsevier
E Jouanguy, R Döffinger, S Dupuis, A Pallier, F Altare, JL Casanova
Current opinion in immunology, 1999•ElsevierThe development of gene-knockout mice and the identification of gene-deficient humans
have improved our understanding of the role of IL-12 and IFN-γ in host defense. Comparison
of experimental and natural infections has shown that animals and humans genetically
deficient in immunity mediated by IL-12 or IFN-γ are highly susceptible to mycobacteria and
salmonella. Impaired secretion of, or response to, IFN-γ is the common pathogenic
mechanism that accounts for impaired granuloma formation and uncontrolled growth of …
have improved our understanding of the role of IL-12 and IFN-γ in host defense. Comparison
of experimental and natural infections has shown that animals and humans genetically
deficient in immunity mediated by IL-12 or IFN-γ are highly susceptible to mycobacteria and
salmonella. Impaired secretion of, or response to, IFN-γ is the common pathogenic
mechanism that accounts for impaired granuloma formation and uncontrolled growth of …
The development of gene-knockout mice and the identification of gene-deficient humans have improved our understanding of the role of IL-12 and IFN-γ in host defense. Comparison of experimental and natural infections has shown that animals and humans genetically deficient in immunity mediated by IL-12 or IFN-γ are highly susceptible to mycobacteria and salmonella. Impaired secretion of, or response to, IFN-γ is the common pathogenic mechanism that accounts for impaired granuloma formation and uncontrolled growth of bacteria within macrophages. The axis formed between IL-12 and IFN-γ is essential for protective immunity against mycobacteria and salmonella in mice and men.
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