[HTML][HTML] Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism
L Li, LM Grønning, PO Anderson, S Li… - Journal of Biological …, 2004 - ASBMB
The suppressors of cytokine signaling (SOCS) family is thought to act largely as a negative
regulator of signaling by cytokines and some growth factors. Surprisingly, the SOCS-6
transgenics had no significant defects in the cytokine signaling and hematopoietic system
but displayed significant improvements in glucose metabolism. Insulin stimulation of
Akt/protein kinase B was also potentiated. Biochemical analysis showed that, after insulin
stimulation, SOCS-6 interacted with the monomeric p85 subunit of class-Ia phosphoinositide …
regulator of signaling by cytokines and some growth factors. Surprisingly, the SOCS-6
transgenics had no significant defects in the cytokine signaling and hematopoietic system
but displayed significant improvements in glucose metabolism. Insulin stimulation of
Akt/protein kinase B was also potentiated. Biochemical analysis showed that, after insulin
stimulation, SOCS-6 interacted with the monomeric p85 subunit of class-Ia phosphoinositide …