[HTML][HTML] Insulin induces suppressor of cytokine signaling-3 tyrosine phosphorylation through janus-activated kinase
P Peraldi, C Filloux, B Emanuelli, DJ Hilton… - Journal of Biological …, 2001 - ASBMB
Suppressor of cytokine signaling (SOCS) proteins were originally described as cytokine-
induced molecules involved in negative feedback loops. We have shown that SOCS-3 is
also a component of the insulin signaling network (1). Indeed, insulin leads to SOCS-3
expression in 3T3-L1 adipocytes. Once produced, SOCS-3 binds to phosphorylated tyrosine
960 of the insulin receptor and inhibits insulin signaling. Now we show that in 3T3-L1
adipocytes and in transfected COS-7 cells insulin leads to SOCS-3 tyrosine phosphorylation …
induced molecules involved in negative feedback loops. We have shown that SOCS-3 is
also a component of the insulin signaling network (1). Indeed, insulin leads to SOCS-3
expression in 3T3-L1 adipocytes. Once produced, SOCS-3 binds to phosphorylated tyrosine
960 of the insulin receptor and inhibits insulin signaling. Now we show that in 3T3-L1
adipocytes and in transfected COS-7 cells insulin leads to SOCS-3 tyrosine phosphorylation …