Autoreactive T cells in human type 1 diabetes
TIM Tree, M Peakman - Endocrinology and Metabolism Clinics, 2004 - endo.theclinics.com
It has been a continued source of frustration to scientists and clinicians working on human T-
cell biology in type 1 diabetes (T1D) that their reviews and research articles on this topic
require a preface acknowledging that the evidence that these cells exist is controversial and
that they cause diabetes is only circumstantial. There can be little doubt, however, that in the
last decade, progress has been made, albeit occasionally in a ''two steps forward, one step
back''fashion. T cells with true autoreactive potential, with autoantigen-specific receptors …
cell biology in type 1 diabetes (T1D) that their reviews and research articles on this topic
require a preface acknowledging that the evidence that these cells exist is controversial and
that they cause diabetes is only circumstantial. There can be little doubt, however, that in the
last decade, progress has been made, albeit occasionally in a ''two steps forward, one step
back''fashion. T cells with true autoreactive potential, with autoantigen-specific receptors …