Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes
GS Eisenbarth, H Moriyama, DT Robles, E Liu, L Yu… - Autoimmunity …, 2002 - Elsevier
GS Eisenbarth, H Moriyama, DT Robles, E Liu, L Yu, S Babu, M Redondo, P Gottlieb…
Autoimmunity reviews, 2002•ElsevierType 1 diabetes of both the NOD mouse and man is associated with autoimmunity directed
against insulin which is the only beta cell specific autoantigen identified to date. One can
use autoantibodies to insulin to predict diabetes, use insulin peptides to create insulin
autoantibodies, insulitis and diabetes, and use insulin or its peptides in animal models to
prevent diabetes. An expanding set of resources are now available for the development and
testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin …
against insulin which is the only beta cell specific autoantigen identified to date. One can
use autoantibodies to insulin to predict diabetes, use insulin peptides to create insulin
autoantibodies, insulitis and diabetes, and use insulin or its peptides in animal models to
prevent diabetes. An expanding set of resources are now available for the development and
testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin …
Type 1 diabetes of both the NOD mouse and man is associated with autoimmunity directed against insulin which is the only beta cell specific autoantigen identified to date. One can use autoantibodies to insulin to predict diabetes, use insulin peptides to create insulin autoantibodies, insulitis and diabetes, and use insulin or its peptides in animal models to prevent diabetes. An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway.
Elsevier