C3a and C5a enhance granulocyte adhesion to endothelial and epithelial cell monolayers: epithelial and endothelial priming is required for C3a-induced eosinophil …
MA Jagels, PJ Daffern, TE Hugli - Immunopharmacology, 2000 - Elsevier
Effects of the anaphylatoxins C3a and C5a on eosinophil and neutrophil adhesion to
HUVEC and to primary culture human bronchial epithelial cells (HBEC) were investigated.
Activities on both leukocytes and on structural cells were examined. C3a upregulated β2
integrin expression and caused shedding of L-selectin on eosinophils, but had no effect on
neutrophil adhesion molecule expression. C5a upregulated β2 integrins and caused
shedding of L-selectin on both eosinophils and neutrophils. The potency of C5a was …
HUVEC and to primary culture human bronchial epithelial cells (HBEC) were investigated.
Activities on both leukocytes and on structural cells were examined. C3a upregulated β2
integrin expression and caused shedding of L-selectin on eosinophils, but had no effect on
neutrophil adhesion molecule expression. C5a upregulated β2 integrins and caused
shedding of L-selectin on both eosinophils and neutrophils. The potency of C5a was …