Publisher Summary This chapter focuses on recent studies that provide results from in vivo
experiments supporting the role for innate immunity in directing or “instructing” the humoral
response. It also explores the recent studies that support the role for natural immunity in
negative selection of self-reactive B cells. The importance of microbial products as adjuvants
in boosting the immune response to noninfectious antigens is well accepted. A connection
between adjuvants and the innate immune response has been made within the last decade …