Complement defense mechanisms
S Tomlinson - Current opinion in immunology, 1993 - Elsevier
Current opinion in immunology, 1993•Elsevier
The susceptibility of complement-deficient individuals to various severe infections, and
studies of the effector mechanisms involved in the destruction of infectious agents,
demonstrate the importance of complement in providing an effective host defense system. It
is also becoming increasingly apparent that complement not only plays a role in
'natural'defenses against infection and in enhancing the antibody-mediated effector
mechanisms, but also influences adaptive immune responses directly.
studies of the effector mechanisms involved in the destruction of infectious agents,
demonstrate the importance of complement in providing an effective host defense system. It
is also becoming increasingly apparent that complement not only plays a role in
'natural'defenses against infection and in enhancing the antibody-mediated effector
mechanisms, but also influences adaptive immune responses directly.
Abstract
The susceptibility of complement-deficient individuals to various severe infections, and studies of the effector mechanisms involved in the destruction of infectious agents, demonstrate the importance of complement in providing an effective host defense system. It is also becoming increasingly apparent that complement not only plays a role in ‘natural’ defenses against infection and in enhancing the antibody-mediated effector mechanisms, but also influences adaptive immune responses directly.
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