[HTML][HTML] Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of …
K Fukuhara-Takaki, M Sakai, Y Sakamoto… - Journal of Biological …, 2005 - ASBMB
In the early stage of atherosclerosis, macrophages take up chemically modified low density
lipoproteins (LDL) through the scavenger receptors, leading to foam cell formation in
atherosclerotic lesions. To get insight into a role of the scavenger receptors in diabetes-
enhanced atherosclerotic complications, the effects on class A scavenger receptor (SR-A) of
high glucose exposure in vitro as well as the diabetic conditions in vivo were determined in
the present study. The in vitro experiments demonstrated that high glucose exposure to …
lipoproteins (LDL) through the scavenger receptors, leading to foam cell formation in
atherosclerotic lesions. To get insight into a role of the scavenger receptors in diabetes-
enhanced atherosclerotic complications, the effects on class A scavenger receptor (SR-A) of
high glucose exposure in vitro as well as the diabetic conditions in vivo were determined in
the present study. The in vitro experiments demonstrated that high glucose exposure to …