[HTML][HTML] Hetero-oligomeric assembly of P2X receptor subunits: specificities exist with regard to possible partners
P2X receptors are a distinct family of ligand-gated ion channels activated by extracellular
ATP. Each of the seven identified subunit proteins (P2X 1 through P2X 7) has been reported
to form functional homo-oligomeric channels when expressed in heterologous systems.
Functional studies of native receptors, together with patterns of subunit gene expression,
suggest that hetero-oligomeric assembly among members of this family may also occur. This
prediction is supported by reports describing hetero-oligomeric assembly for three different …
ATP. Each of the seven identified subunit proteins (P2X 1 through P2X 7) has been reported
to form functional homo-oligomeric channels when expressed in heterologous systems.
Functional studies of native receptors, together with patterns of subunit gene expression,
suggest that hetero-oligomeric assembly among members of this family may also occur. This
prediction is supported by reports describing hetero-oligomeric assembly for three different …