[HTML][HTML] Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors: Ser-333 and Ser-334 in the carboxyl terminus are involved in agonist …
AE Brinson, TK Harden - Journal of Biological Chemistry, 2001 - ASBMB
Agonist-promoted regulation of the uridine nucleotide-activated human P2Y4 receptor
(P2Y4-R) and P2Y6 receptor (P2Y6-R) was studied. Incubation of P2Y4-R-expressing
1321N1 human astrocytoma cells with the cognate agonist UTP resulted in rapid
desensitization of the inositol phosphate response and a 50% loss of cell surface receptors.
In contrast, incubation of P2Y6-R-expressing cells with the cognate agonist UDP caused
neither rapid desensitization nor rapid loss of cell surface receptors. Removal of UTP from …
(P2Y4-R) and P2Y6 receptor (P2Y6-R) was studied. Incubation of P2Y4-R-expressing
1321N1 human astrocytoma cells with the cognate agonist UTP resulted in rapid
desensitization of the inositol phosphate response and a 50% loss of cell surface receptors.
In contrast, incubation of P2Y6-R-expressing cells with the cognate agonist UDP caused
neither rapid desensitization nor rapid loss of cell surface receptors. Removal of UTP from …