Neuropathic pain is a debilitating chronic syndrome that often arises from injuries to
peripheral nerves. Such pain has been hypothesized to be the result of an aberrant
expression and function of sodium channels at the site of injury. Here, we show that
intrathecal administration of specific antisense oligodeoxynucleotides (ODN) to the
peripheral tetrodotoxin (TTX)-resistant sodium channel, NaV1. 8, resulted in a time-
dependent uptake of the ODN by dorsal root ganglion (DRG) neurons, a selective 'knock …