The systemic administration of anti-nerve growth factor (NGF) antibodies can prevent local
sensory hypersensitivity and block nociceptive fibers from sprouting into denervated adult rat
skin. However, in the case of chronic constriction injury (CCI) in a rat, there is evidence that
NGF reverses some effects of axotomy and alleviates thermal hyperalgesia. It is with this in
mind that we investigated the influence of local anti-NGF and NGF on neuropathic pain and
collateral sprouting caused by CCI. In our study, we looked at the effects to the ligated …