Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy
JG Cui, S Holmin, T Mathiesen, BA Meyerson… - Pain, 2000 - Elsevier
Peripheral hypersensitivity (hyperalgesia and allodynia) are common phenomena both in
inflammatory and in neuropathic pain conditions. Several rat models of mononeuropathy
(Bennett, Seltzer and Gazelius models) display such symptoms following partial injury to the
sciatic nerve. Using immunohistochemistry and behavioral tests, we investigated
inflammatory cell and cytokine responses in the sciatic nerve 14 days after injury created in
these different models as well as after axotomy. Tactile hypersensitivity ('allodynia') was …
inflammatory and in neuropathic pain conditions. Several rat models of mononeuropathy
(Bennett, Seltzer and Gazelius models) display such symptoms following partial injury to the
sciatic nerve. Using immunohistochemistry and behavioral tests, we investigated
inflammatory cell and cytokine responses in the sciatic nerve 14 days after injury created in
these different models as well as after axotomy. Tactile hypersensitivity ('allodynia') was …